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The Next Iteration Podcast

@nextiterationpod

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Enabling the best iteration of yourself.
Featuring hosts @tofuadmiral & @damienrjoseph
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There’s a part of us that desperately wants the truth even when the truth won’t help. Maybe it’s the morbid curiosity that seems to come stock with the human condition.

Not to feel better. Not to get ahead. Just to know.

#harvard University philosopher Dr. Susanna Rinard built her career on a view that seems to leave no room for that impulse: judge beliefs by their consequences, the same way you judge actions (‼️also voted 1 of the Top 10 best philosophy papers of the year‼️). In the clip below, she begins to explain why it does.

It’s the thread that runs through our whole conversation on the newest episode of The Next Iteration Podcast. We tested her view against Santa Claus, placebo surgery, conspiracy theories and Pascal’s Wager, and kept finding that the true belief is usually the useful one. The exceptions are narrower than you’d expect.

Then we turned to her Harvard course on happiness. Why chasing good feelings leaves people hollow while sacrifice fills them up. Why so many high-achievers stay in jobs they know are hurting them. And why stoicism sells in a way the same advice on a greeting card never could. by @nextiterationpod

Is God able to prevent evil, but not willing? Then why call him God?
Epicurus asked it two thousand years ago. Leibniz spent a life answering it. And this week, we handed the whole tangle to Harvard’s Dr. Jeffrey McDonough, who somehow took us from the problem of evil to the inner life of an AI token, and left us laughing about why philosophers were so afraid to laugh.

Jeff is the chair of philosophy at Harvard and one of the world’s leading scholars on Gottfried Wilhelm Leibniz — the 17th-century polymath who co-invented calculus, designed the binary system, and dreamed of an encyclopedia of all human knowledge three centuries before the internet made it look ordinary.

We came with our thinking hats on. We asked why there’s something rather than nothing. We pressed on his claim that this is the “best of all possible worlds,” and watched it hold up against Epicurus, Voltaire, and Aquinas. We chased a parallel we couldn’t shake between Leibniz’s monads and the tokens quietly shaping how machines now think. And we ended somewhere we didn’t expect: the philosophy of humor, and the uncomfortable question of whether you can ever really separate the art from the artist.

As always, we ran out of time long before we ran out of questions.

Fellow philosophy nerds let us know your thoughts and what you wished we asked! by @nextiterationpod

We’re all trying to make sense of AI’s impact; not just on our jobs, but on our mental models and inner lives.

On this week’s episode of The Next Iteration Podcast, Damien, and I sat down with Aman Khan. He’s an AI product leader, a colleague of mine at Arize AI, and one of the clearest thinkers I know.

We delved into what it actually means to be an hashtag
#AI PM, why this role is evolving faster than any other in tech, and how AI is quietly rewriting the way we make decisions, build products, and navigate our careers.

But this convo wasn’t just about work. Aman opened up about the habits that have kept him grounded and why he thinks the future might require mind gyms as much as physical ones. 🏋🏽‍♀️

If you’re curious about the future of work, personal operating systems, or how to stay human in an AI-saturated world, this one’s worth a listen.

Link in the bio to listen on all platforms 👇 (hope we lived up to Lenny Rachitsky ’s great interview with Aman too ;) ) by @nextiterationpod

A tool as powerful as AI means there’s going to be people inevitable wielding it for.. unsavory purposes. This basically means we’ve gone from regular ol’ cybercrime to agentic AI cybercrime™.

Sai Huda joins us on the next iteration podcast to give us the run down on the how the landscape [cyberscape?] of cybersecurity has evolved with the advent of AI and also helps us out with some practical tips on how to protect yourself. Sai is the CEO at Cybercatch, author of Next Level Cybersecurity, and is a globally recognized expert in risk and cybersecurity.

Tune in to hear from one of the leading authorities on the matter and learn about why this is so important and why it should matter to you!

Timestamps:
(5:00) - Actual advice to make you more secure
(9:00) - The PR issue of Cybersecurity -> Risk and Compliance
(20:00) - What does CyberCatch do?
(24:00) - Russian CyberGangs™
, The Lazarus Group
(31:00) - A tale as old as time: Agent on Agent Violence // Security in the Age of AI
(42:00) - MFA is your Biggest Security Weapon
(48:00) - How do we Incentivize Hacking for “Good”? by @nextiterationpod

@maikothecreator the researcher and rapper himself, joins us on today’s Next Iteration Podcast episode to talk rap, genetics, and growing up as a Vietnamese Canadian in Toronto :) link in bio for full episode.

GO LISTEN TO HIS ALBUM HERE TOO @theatticsofficial

Super wide ranging convo that you don’t want to miss! #podcast #genetics #research

(3:39) – Genetic engineering as a film genre
(5:59) – He Jiankui and gene editing
(19:19) – Michael’s origin story
(35:09) – The Canadian dream
(42:39) – 2024 Nobel Prize in Economics
(47:49) – If you could do a PhD on anything, what would it be
(50:49) – Your body stores memories
(52:11) – Gut microbiome
(56:56) – Reductionism in scientific research
(1:00:28) – Nobel laureates and creative hobbies
(1:04:24) – Michael and music by @nextiterationpod

What’s it like to leave Italy at 17, dive into Wall Street, then become a VC at one of the top firms in Silicon Valley? Or what it means to actually be a partner, when so many firms throw the title around?

Today on The Next Iteration Podcast, we’re joined by Carlotta “Lotti” Siniscalco of Emergence Capital —an absolute force in early-stage fintech and enterprise investing, and a fierce advocate for #womenInVenture. Trust us, this one’s a gem. Link in bio to listen on all platforms 💎

P.S. She also talks a bit of shop about the amazing Federato and Emergence’s decision to invest! :)

Timestamps:
(8:45) - Being the #blacksheep and non-consensus opinions
(15:30) - Immigrating to the US from #Italy at 17
(20:45) - Is America still the #landOfOpportunity, or should we all move to Europe?
(28:30) - Thesis-driven #investment and conviction areas
(38:50) - Emotional Intelligence: the difference between a good and a great VC
(43:45) - What do you do as a board member?
(49:00) - How to get more women into VC by @nextiterationpod

Women experience war differently from men, and I can’t believe I’ve never thought about it before.

It’s impossible to paint a picture of trauma with broad brushstrokes because it’s such a personal experience.

Our conversation with Anne Naclerio on The Next Iteration Podcast opened our eyes to this reality in such a raw way. She is the former Chief Surgeon of the US Army National Guard , co-author of the book Women at War, and presently serves as the Chief Medical Officer at Polaris Genomics, a company dedicated to bringing biological clarity and objectivity to the assessment, diagnosis, and treatment of mental health and neuropsychiatric conditions.

We couldn’t have asked for a better messenger. by @nextiterationpod

Psychedelics will make you rethink your whole life.

Despite the recent inflection in openness to it, fact remains that it’s still uncomfortable for many to talk about; if not outright rejecting it.

But maybe in a modern age what we’ve been missing is in fact ancestral [plant] wisdom..?

—

Doug Drysdale is the CEO of Cybin Inc, a company leading the charge in this psychedelic research renaissance on a mission to revolutionize mental healthcare by engineering proprietary drug discovery platforms, innovative drug delivery systems, novel formulation approaches and treatment regimens to address the unmet needs of patients across a multitude of mental health issues.

And in the midst of a mental health epidemic, what better time to do so than the present?

He joins Fuad Ali and I on the latest episode of the The Next Iteration Podcast to discuss his life, work, and thoughts—philosophical and otherwise—on the implications of a world with greater access to psychedelics. by @nextiterationpod

There’s a new regime in town, and they’re starting to seriously think about #Bitcoin.

A strategic reserve, Senator Cynthia Lummis’ BITCOIN act going to Congress, BTC at 100K? What is going on?!?

What better way to start your holidays than to spend time with Keeyan Ravanshid and hear him explain Crypto, Entrepreneurship, and what the future of regulation looks like in the Blockchain universe?

Listen to the latest The Next Iteration Podcast episode to hear Damien discuss these and more. Link in comments to listen on all platforms.

Timestamps:
(2:00) To Be or Not To Be a Crypto Bro?
(8:40) Why are you interested in entrepreneurship?
(20:10) Why Crypto?
(29:00) Why does crypto mean the monetary system has to change?
(40:00) A RENEWAL - Things Need to Change
(48:00) The BITCOIN Act in Congress
(55:00) Real world examples of Blockchain
(1:09:00) Bitcoins energy consumption index
(1:24:00) The State of Canada

#podcast #crypto #blockchain #bitcoin #BTC #politics

@keeyanrav @damienrjoseph @tofuadmiral by @nextiterationpod

Why can’t publication-grade science be a hobby?   Why can’t we just explore for the sake of it? When you play basketball with your friends, you’re just playing ball; not everyone is trying to go to the NBA.   Imagine a world where ANYONE can contribute meaningfully to “hard” sciences like biology.   That’s the world @Sebastian Cocioba envisions, and @Damien and I would love to see it become a reality :)   Tune into today’s Next Iteration #Podcast Episode to hear more about Sebastian’s super cool work, background, and vision for the future of biology. Truly a lovely conversation.

Timestamps
(8:30) - #AI Tools for #Researchers
(22:00) - #Science is Structured Play (31:00) - How to Grow Almost Anything (35:00) - #Flowers for Everyone (41:00) - Designing Science Education (49:00) - Explore for the Sake of It (1:09:00) - Go for a Beer with Failure by @nextiterationpod

Ahhh man, a top-five podcast episode for sure.

Moments where you can get two cofounders who’ve known each other for years debating a topic they’ve never talked about are what Damien and I do The Next Iteration Podcast FOR.

Today’s episode features Nathaniel Salander and Rasmus Dey Meyer, the founders of Apollo Defense. #Defense is a prickly topic; there’s a TON of opinions on both sides of the aisle. Honestly, I felt uncomfortable doing an episode on it for a long time, since I didn’t want to get "#political".

If you’ve ever wanted to understand the global landscape, America’s role in international relations, and how tech plays a role, THIS IS THE EPISODE FOR YOU.

Truly, one of my favorite conversations on the podcast yet. Link in comments for the full episode (on all platforms).

Timestamps
(2:10) - What are Segundo Bros?
(5:30) - What can young people do in Defense?
(11:44) - $1000 drones taking out 3 billion dollar ships
(25:20) - Deterrence Theory and Francis Fukuyama
(40:50) - The Valley of Death for Defense Startups
(55:00) - The Trickle-Down Effect of Defense Tech by @nextiterationpod

Shoutout the homie @parthsareen_ for hopping on the podcast to talk about his startup, Extensible, tech Twitter 👀 and all things Gen AI. If you're interested in building or investing in #AI this is the one for you :) by @nextiterationpod