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Key Facts About U.S. Blood Needs Daily Need: Roughly 29,000 units of red blood cells, 5,000 units of platelets, and 6,500 units of plasma are transfused every day in the U.S. Frequency: Someone in the U.S. needs blood or platelets approximately every 2 seconds. Donor Gap: While about 38% of the U.S. population is eligible to give blood, only around 3% donate annually, leaving national supplies routinely vulnerable to regional shortages.