Prathmesh Bhosale | Weightloss, Diabetes, Pcos, Thyroid, Fitness

Comment “heart health” get free ebook. The story begins with insulin resistance, long before someone experiences chest pain.
Here’s the fascinating biochemistry behind it.
1. 🧬 Insulin resistance develops → Muscle, liver and fat cells respond less effectively to insulin, so the pancreas often compensates by producing more insulin.
2. 🔥 Blood vessels become vulnerable → Insulin resistance is associated with endothelial dysfunction, oxidative stress and chronic low-grade inflammation.
3. 🩸 Nitric oxide signalling weakens → Impaired insulin signalling can reduce nitric oxide availability, making blood vessels less able to relax.
4. 🧈 Atherogenic lipoproteins increase → Higher VLDL, triglycerides and small dense LDL particles often accompany insulin resistance, increasing cardiovascular risk.
5. 🫀 Plaque gradually develops → ApoB-containing lipoproteins enter the artery wall, triggering inflammation and plaque formation over many years.
6. 🚨 A heart attack occurs → A plaque can rupture or erode, triggering a blood clot that suddenly blocks coronary blood flow.
The important distinction: Insulin resistance can contribute to this process, but it does not determine that a heart attack will happen exactly 10 years later. Smoking, LDL cholesterol, blood pressure, genetics and other factors also matter.
[ prevent heart attack, save heart attack ]
This video is to deliver education in simple terms not med advice ]