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A new drug being trialled at The Christie has the potential to make immunotherapy effective where it hasn't been before.Immunotherapies harness the body's immune system to find and attack cancer cells.The pill, currently called GRWD5769, has shown promise in shrinking tumours or keeping them stable in six advanced and hard-to-treat cancers - cervical, bladder, liver, non-small cell lung cancer, squamous cell carcinoma of the head and neck and a type of bowel cancer called microsatellite stable bowel cancer.Every patient who benefitted had already failed treatment, and most had no conventional treatment options left after multiple lines. Crucially, immunotherapy hadn't worked or had stopped working.Some people on the EMITT-1 trial saw their tumours shrink by 30% or more.The drug works by targeting an enzyme called ERAP1, which cancer cells use to hide from the immune system.When paired with Cemiplimab, an existing immunotherapy, it frees up the patient’s immune system to allow it to target the cancer on its own.💬Professor Fiona Thistlethwaite, Consultant Medical Oncologist, is leading the trial at The Christie: “Immunotherapy has been a game-changer in the way we treat cancer, but the number of people that can benefit is still relatively low. “What excites me about this trial is the combination of what we’re seeing - strong signals of efficacy across six tumour types that have shown great resistance to immunotherapy, with very few side effects. That's unusual at such an early stage when we’re usually just looking at how safe it is. “There’s a lot more work to be done before it reaches the clinic, but for a brand-new drug to show that kind of profile so early, and in so many different types of hard-to-treat cancers, gives me genuine optimism.”Follow the link in bio to learn more about the drug and the trial. by @thechristienhs
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1 dzień temu
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During her visit to The Christie, The Princess of Wales chatted to patients and staff across the hospital.These personal conversations meant so much to everyone who spoke to her.20-year-old Maison Shaw, who met Her Royal Highness in our Teenage and Young Adult unit, said:💬 "It means a lot to speak to people like The Princess because they actually understand what it's like to go through all the tough treatments and how you actually feel alongside the treatments and how rough they can be."Thank you so much to Her Royal Highness for visiting our hospital, and to all the patients and staff involved. by @thechristienhs
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3 dni temu
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The Christie Charity Team Meet Her Royal Highness The Princess of Wales!We were delighted to speak with The Princess today at The Christie. The Princess visited a number of Charity funded departments across the hospital including the Art Room, Grounds and Gardens and The Christie's chemotherapy unit which was built using funds raised by The Christie Charity.We are touched that our work was recognised by The Princess when she commented on the 'fantastic, extraordinary job' we are doing and how lucky the Trust is to have such a supportive and active charity. The Princess also recognised the importance of the Charity funded 'crucial' therapy and wellbeing offers across the hospital before wishing us luck in fundraising for a brand new scanning centre. by @thechristienhs
227
6 dni temu
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Her Royal Highness The Princess of Wales came to our Withington site today. The visit focused on how we support people’s physical, mental, emotional, and spiritual wellbeing while they’re going through cancer treatment. Her Royal Highness first met patients having chemotherapy at the Oak Road Treatment Centre, including Claire, who had just rung the end-of-treatment bell.She then took a tour of the hospital and garden, chatting with patients who have benefited from our complementary therapy, art, and spiritual care services, as well as with the staff involved. The Princess rounded off the day by visiting the Teenage and Young Adult (TYA) unit to speak to staff, young patients , and their families about the social and recreational activities designed to support young people as they navigate an especially challenging time. 💬Roger Spencer, our CEO, comments: “We were delighted to welcome Her Royal Highness The Princess of Wales. “Having cancer affects every area of someone’s life, and we’re proud to have a person-centred approach to care that focuses on the individual, and not just their diagnosis. “Our art room, complementary therapy service and TYA unit mean so much to people here, and it was an honour to introduce The Princess to the patients and staff involved.” Follow the link in bio to read more about the visit. @princeandprincessofwales by @thechristienhs
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6 dni temu
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Aileen Pritchard was able to avoid having chemotherapy for breast cancer thanks to an experimental gene test she had at The Christie. 🧬 The OPTIMA study evaluated the effectiveness of the Prosigna test, which assesses the activity of genes involved in breast cancer growth. The results, which were presented at the American Society of Clinical Oncology meeting last week, suggest that people aged 40 and over whose tumours have a low Prosigna test score can be treated safely with hormone therapy alone, potentially transforming care for thousands of patients each year.Of the 4,429 people who took part in the trial, more than two-thirds (68%) had a low score.For this group, the results showed that outcomes were very similar whether chemotherapy was given or not.The trial recruited people aged 40 or older following surgery for hormone-sensitive breast cancer. Most had their cancer spread to underarm lymph nodes, which placed them at high risk of future recurrence. Results for the full trial population will inform decision-making on whether the test will be made available on the NHS.💬 Reflecting on her experience of the trial, Aileen says:“If I had to have chemotherapy, I probably would have had to stop working, and we might have lost our livelihood, which would have been disastrous. I can still picture where I was and how I felt when the nurse told me the news – I could almost feel the weight lifting off my shoulders. It was a huge relief.“Being able to live the best life possible during cancer treatment is so important for both your physical and mental health. I was able to do all the things I love, like going swimming three to four times a week and getting away for the weekend with Kevin.“It’s great that the results show that this test works, and I hope that more people will be able to benefit from it in the future. I had no reservations about joining the trial. Science and medicine can’t advance without research, so I was glad to play my part in helping people like me in the future.”Follow the link in bio to learn more. 🔗 by @thechristienhs
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7 dni temu
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"What does volunteering mean to you?"This National Volunteers' Week, some of our volunteers are sharing what they love about their roles.Thank you to all our volunteers for the invaluable contribution you make to our hospital.Follow the link in bio to learn more about volunteering at The Christie. by @thechristienhs
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9 dni temu
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Doctor-in-training Charlotte Russell has paused her medical studies to do a PhD in cancer research. 🔬 Based at the Manchester Cancer Research Centre on the Christie site in Withington, she’s looking into why people under 60 are more likely to have cancer that spreads to the brain than older adults. Charlotte, who wants to be an oncologist when she finishes her training, recently spent time with two Christie consultants and their patients in the clinic. “I was so impressed with the all-encompassing and compassionate nature of the care at The Christie. I was in the oesophageal cancer clinic, so in addition to the consultant and nurse, patients also got support from other experts like dieticians. It was great to see how everything works,” she says. “Spending time in the hospital itself helped to bring home why cancer research is so crucial. It helps you understand the patient experience and how your own research can improve lives,” she says. “It has motivated me to pursue a career as an oncologist involved in research once I’ve qualified.” by @thechristienhs
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13 dni temu
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47-year-old Jodie Goulborn from Merseyside has a type of brain tumour called a glioma. 🧠 A ground-breaking new drug called vorasidenib has been keeping it at bay for over 4 years, and now that drug is available on the NHS. It’s the first time a new adult brain tumour treatment has been approved in 20 years.Jodie, who has been married to John for 15 years, was one of the last patients to sign up to the trial that showed the new pill's effectiveness. To be eligible, she needed to have a grade 2 glioma with an IDH1 or IDH2 mutation. She also needed to have had surgery but no other treatment.Jodie started on the drug at the end of 2021, and her cancer has remained stable since then. 💬 She says it's had a transformative effect on her life:“Before starting on the trial, both my physical and mental health were suffering. I was getting bad migraines and head pain in the area where the tumour was sitting. Obviously, that was stopping me from doing the things I loved, but I was also constantly worried about what was going on. I couldn’t stop thinking about it. It didn’t take long after being on the trial that the pain disappeared and the migraines decreased in frequency.“The difference that the drug has had on my physical and mental health has been remarkable. I recently started a new job in the Probation Service and would never have had the confidence to do that if it wasn’t for the trial. It’s changed me as a person.“I’m so happy to hear that it’s now been approved on the NHS. To know now that other people will be able to have it means the world to me.” by @thechristienhs
0
15 dni temu
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“I wear a hat in the sun and factor 50, and I would encourage everyone to do the same. Keeping safe in the sun is really important – it could save your life.”51-year-old Claire Jordan from Nantwich had two successful surgeries for melanoma skin cancer at Leighton Hospital and The Christie last year. Claire, who was a fan of sunbeds and spent years soaking up the sunshine while travelling the world as an air steward, was diagnosed after she went to her GP about a mole she was concerned about.“When I noticed a mole on my neck had changed colour and shape, my first thoughts were that maybe I had scratched or knocked it and that it would heal and look normal again,” she said. “But I plucked up the courage to make an appointment to get it checked out.”Following her operations, Claire was given the all-clear, and no further treatment was needed. Claire said her experience had changed her outlook on having a tan and sunbathing:“I had always been incredibly careful in the sun on holiday, always using plenty of lotion and using a high factor, and didn't think my occasional sunbed use would ever be harmful. But it goes to show that you need to be incredibly careful to protect your skin. I now have the rest of my life ahead of me and have not visited the sunbed shop since,” she adds.Follow the link in bio to read more about staying safe in the sun.🌞 by @thechristienhs
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19 dni temu
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Today is International Clinical Trials Day. The Christie is an international hub for cancer research, and our experts are working on around 700 clinical trials at any one time.Together, they're going to double the number of patients benefitting from trials by 2030.Without advances in science and medicine, there'd be no new cancer treatments. Thank you to all our staff and patients who are involved in research. 💙 by @thechristienhs
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21 dni temu
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Barbara, known as Babs, has worked at The Christie for 30 years as a PA and medical secretary in the lung oncology team.For many patients and families, she’s one of the first people they speak to.“We can be on the phone one minute talking to someone who has just lost their husband, and the next call might be a request for a letter… I try to reassure people so they feel more at ease.”“I feel this shows that I do make a difference, even if it’s in a small way.”Following Admin Professionals Week, we’re proud to share her story and recognise the impact of admin colleagues across the NHS. by @thechristienhs
2
23 dni temu
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“When communication is clearer, living with cancer feels more manageable,” says Lynn, who has been cared for at The Christie since 2017.In our second Future Christie film, Lynn shares how clearer communication, digital note taking and digital treatment reviews are helping her feel more informed and supported between appointments.Future Christie is our programme to improve how cancer care is delivered, helping patients feel more informed, more supported, and more in control through clearer communication and joined-up digital systems.🎥 Watch Lynn’s story by @thechristienhs
0
25 dni temu
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