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A‑Plus Immunity | Pet Wellness
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Is your senior cat yowling at night? It might not just be "old age" 🐱💤
If your extraordinary senior cat (17–18 years old!) has started wandering, getting disoriented, or vocalizing after dark, there is a clear medical reason.
Case Study spotlight: Pearl, a 17-year-old cat, presented with nighttime yowling and litter box changes. Assessment confirmed Feline Cognitive Dysfunction Syndrome, accompanied by elevated IL-1β (a key marker of neuroinflammation) and brain white matter changes.
3 Key Takeaways for Senior Cat Parents: 1️⃣ It's Neuroinflammation: Brain inflammation—not just getting old—causes sleep and behavior changes. Research by Memoli et al. (2025) links high IL-1β directly to sleep disruptions.
2️⃣ Biomarkers Exist: Elevated inflammatory markers like IL-1β can be measured.
3️⃣ Actionable Steps: Simple, targeted support can help:
✨ Adjusted nighttime lighting to reduce disorientation
✨ Omega-3 fatty acids to combat neuroinflammation
✨ Antioxidants (Vitamins E & C) and environmental enrichment
💡 Old age isn't a disease, but neuroinflammation is addressable!
#SeniorCatCare #CatHealth #FelineCognitiveDysfunction #VetMedicine #CatDementia #PetWellness #cats #inflammation #neuroinflammation by @aplusimmunity

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19 hours ago

At 15 years old—roughly 76 to 80 in human years—Chester the domestic shorthair had achieved a remarkable milestone. But severe, two-year bilateral hip and stifle osteoarthritis was making simple daily joys like grooming and jumping difficult, even with frunevetmab and home accommodations in place. 💔
Then came a new horizon in regenerative veterinary medicine 🌿✨
Chester participated in the 2026 Gallant pilot trial testing intravenous uterine-derived mesenchymal stromal cell (UMSC) therapy. Rather than simply dulling pain signals, UMSC treatment targets the dysregulated joint inflammation driving OA at its root cause.
By Day 90 of the placebo-controlled trial: ✨ 76.2% of UMSC-treated cats showed marked CSOM mobility score improvements (vs. 36.4% placebo). ✨ 81% saw improved veterinary pain scores (vs. 45.5% placebo).
Regenerative therapies give cats who have exhausted conventional options a second chance at comfort! 🐾❤️
#SeniorCat #CatCare #VeterinaryMedicine #StemCellTherapy #FelineHealth #CatLovers #PetHealth #RegenerativeMedicine #cats #inflammation by @aplusimmunity

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2 days ago

"Slowing down" isn't always just getting old 🐱❤️
When 14-year-old Mabel came in for her wellness check, her owner noticed subtle changes in her activity. Her physical exam showed a low Body Condition Score (3/9) and marked muscle wasting along her spine and hindquarters.
A full diagnostic workup uncovered several overlapping health issues:
1️⃣ IRIS Stage 2 Chronic Kidney Disease
2️⃣ Hyperthyroidism & mild anemia 3️⃣ Lumbosacral spinal pain & severe dental disease
4️⃣ Mild cognitive dysfunction
Her personalized care plan combined thyroid medication (Methimazole), a renal diet with phosphorus binders, targeted pain relief (Frunevetmab), a dental cleaning, high-protein digestible food, and Omega-3 supplements.
💡 The Big Lesson: In senior cats, inflammatory conditions fuel each other. Addressing the underlying inflammatory network helps multi-morbid senior cats maintain comfort and quality of life!
#SeniorCatCare #VeterinaryMedicine #FelineHealth #VetMed #CatWellness #VeterinaryCaseStudy #cats #inflammation by @aplusimmunity

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3 days ago

Meet Apollo! 🐾 At 11 years old, this handsome Siamese boy started showing subtle senior health changes: drinking more water, losing weight, and vomiting occasionally.
When his vet ran diagnostics, bloodwork revealed elevated creatinine (3.1 mg/dL) and high Serum Amyloid A (SAA)—an important marker of systemic inflammation. Apollo was diagnosed with IRIS Stage 3 Chronic Kidney Disease (CKD).
To protect his kidneys, his team created a comprehensive treatment plan:
✨ Specialized renal diet
💧 Subcutaneous fluid therapy 3x weekly
💊 Phosphorus binder
🐟 Anti-inflammatory Omega-3 fatty acids (EPA/DHA)
The Result? At his 6-month checkup, Apollo’s inflammation marker (SAA) decreased and his creatinine stabilized! 🎉
🎥 Watch his full story in our new video, "Saving Apollo's Failing Kidneys"!

#SeniorCat #CatKidneyDisease #FelineHealth #SiameseCat #CatParents #PetCareTips #VetCare #cats #inflammation by @aplusimmunity

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4 days ago

Is your cat secretly slowing down? 🐱💬
By ages 8–9 (~50 human years), cats enter a middle-aged transition marked by inflammaging, gut microbiome shifts, and hidden joint pain. Research shows 82% of mature cats have orthopedic examination abnormalities.
Since cats naturally hide discomfort, watch for these subtle warning signs: ✨ Reluctance to jump to favorite spots ✨ Changes in grooming habits or litter box routine ✨ Increased sleeping or reduced overall activity
Case Study Highlight: "Duchess," a 9-year-old cat who stopped jumping onto her owner's bed, was diagnosed with bilateral stifle osteoarthritis. Thanks to targeted anti-NGF monoclonal antibody therapy and fish oil supplementation, she was back to jumping in just 30 days!
▶️ Watch the video to learn what to watch for in your middle-aged cat!
#CatCare #CatHealth #FelineOsteoarthritis #VetTips #CatLover #PetWellness by @aplusimmunity

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5 days ago

Most veterinary professionals know that chronic kidney disease affects 30%+ of cats over 12. Fewer know that the inflammatory process driving CKD is measurable — and potentially modifiable — years before clinical signs appear. Swipe to review 6 clinical case studies, a spay/neuter analysis, relevant for veterinarians, veterinary technicians, and engaged cat owners alike. #cats #inflammation #agerelated by @aplusimmunity

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10 days ago

Case Study: The Overweight Six-Year-Old
Background: A six-year-old neutered male domestic shorthair, "Biscuit," presented for a routine wellness exam. Body condition score (BCS): 8/9 (obese). Weight: 6.8 kg.
Findings: Bloodwork revealed mildly elevated globulins and a reduced albumin-to-globulin ratio. Fasting triglycerides were elevated. No overt disease was identified.
Outcome: A structured weight-loss program was initiated. Over 18 months, Biscuit lost 1.4 kg, and repeat bloodwork showed normalization of globulin levels and improved triglyceride values.
Teaching Point: Obesity at middle age is not cosmetic — it is an active inflammatory state. Intervention at six years old may meaningfully alter the inflammatory trajectory of the next decade. #cats #inflammation by @aplusimmunity

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16 days ago

Ep. 13: The Silent Fire Within: Understanding Chronic Inflammation in Cats. Link in bio.
In this episode, we explore chronic inflammation — the invisible, slow burning process that affects millions of cats. We break down how inflammation works, why it becomes chronic, and how breed genetics shape organ specific risks. You’ll learn: • The difference between acute and chronic inflammation • How inflammation contributes to heart disease, arthritis, neurological issues, and more • Which breeds carry higher inflammatory vulnerabilities • Early warning signs cat parents should watch for • Science backed strategies to support long term feline wellness
A must listen for cat parents, veterinary professionals, and anyone passionate about One Health and preventive care.
#CatHealthPodcast #Inflammation #OneHealth #FelineWellness #APlusNaturals #cats by @aplusimmunity

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17 days ago

Different cat breeds carry different inflammation risks — from heart heavy Maine Coons to joint sensitive Persians. This infographic shows where inflammation strikes first and how cat parents can support long term wellness through nutrition and early care. #CatParents #FelineWellness #HealthyCatsHappyHomes #cats #inflammation by @aplusimmunity

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20 days ago

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21 days ago

Imagine a quiet fire inside your cat’s body — slowly affecting her joints, heart, or even brain. That’s chronic inflammation, and some breeds are more vulnerable than others. Our new video breaks down a breed specific risks, early warning signs, and how to support long term wellness through science backed care.
#CatParents #FelineWellness #Inflammation #HealthyCatsHappyHomes #APlusNaturals #cats by @aplusimmunity

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22 days ago

🎧Ep. 12 - The Silent Fire Within- what every cat parent must know about inflammation - link in bio.
We face a silent challenge: the evolutionary mandate of the feline species to mask vulnerability. In the wild, displaying weakness is an invitation to predation. In domestic environments, this hard-wired instinct means feline patients often suffer from chronic, low-grade systemic inflammation in absolute silence.
In our latest podcast episode, "Why Your Cat Hides Chronic Inflammation," we unpack the neurobiological pathways of feline pain and explore evidence-based, multimodal strategies to detect and mitigate this "silent fire".
Key Takeaways Discussed:
• Behavioral Shifts over Physical Cues: Why a sudden drop in climbing or jumping is a more reliable indicator of osteoarthritic discomfort than limping.
• The Gut-Immune Connection: How spore-forming probiotics like Bacillus subtilis modulate systemic inflammation, lower TNF-α, and upregulate intestinal tight junction proteins.
• Nutritional Anti-Inflammatory Therapeutics: Utilizing targeted Omega-3 fatty acids (EPA/DHA) and prebiotic Larch Arabinogalactan to foster short-chain fatty acid (SCFA) production and support natural killer (NK) cell dynamics.
Listen to the episode to learn how anti-inflammatory nutrition acts as an essential clinical tool for feline longevity.
#VeterinaryMedicine #FelineHealth #PetPainAwareness #AnimalNutrition #ClinicalVeterinary #inflammation #cats by @aplusimmunity

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23 days ago