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@carbogenetics

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Founder and CEO @steve_scottinc
BodyStream
CO2inhaler
CO2 therapy
Oxygenation
Energy
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Mitochondria Biogenesis

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Will be speaking this month at the "beyondconference.com" later this month in Austin Texas.

Looking forward to connecting with everyone in Austin and being part of an incredible event. by @carbogenetics

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5 months ago

Showing the new version of the CO2inhaler at Fields of Wellness in Clearwater Florida last month. The new version uses a digital display and is easier to fine tune the CO2 levels. by @carbogenetics

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2 months ago

What is inside artery plaque?

Go beneath the artery lining to see retained lipid, foam cells, a necrotic core, collagen and calcium. Then see how inward growth, outward remodeling and cap rupture affect the artery. Plaque composition and organization matter alongside narrowing.

From The Carbonated Body
Learn more: https://co2body.com/stevenscott

#Carbogenetics #HeartHealth #Atherosclerosis #CoronaryArteryDisease #TheCarbonatedBody by @carbogenetics

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3 days ago

CO2: An Antioxidant You Make Yourself?

Part 5 explores how CO2 and bicarbonate can alter reaction pathways and oxidant targets. Changing oxidative chemistry is not the same as eliminating oxidation.

A rat hypoxia experiment and an isolated red-cell membrane experiment provide specific experimental clues. Selective mitochondrial cardiolipin protection remains a mechanistic hypothesis with limited direct evidence.

From Chapter 18 of The Carbonated Body
Learn more: https://co2body.com/stevenscott

Study: https://pubmed.ncbi.nlm.nih.gov/18683905/

#Carbogenetics #CarbonDioxide #Mitochondria #LipidPeroxidation #CellBiology by @carbogenetics

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7 days ago

What happens when cardiolipin oxidizes?

Part 4 of the lipid-peroxidation series follows damage to mitochondrial lipid architecture, altered respiratory function, oxidative feedback and impaired ATP production. It also explores cardiolipin's role in cytochrome-c mobilization during apoptotic signaling.

These are context-dependent processes. Cardiolipin oxidation alone does not mean a cell inevitably undergoes apoptosis.

From Chapter 18 of The Carbonated Body
Learn more: https://co2body.com/stevenscott

Next: Can CO2 alter the chemistry before the chain reaction spreads?

#Cardiolipin #Mitochondria #LipidPeroxidation #CellBiology #Carbogenetics by @carbogenetics

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10 days ago

Your mitochondria need this fat: cardiolipin.

Part 3 of the lipid-peroxidation series explores the four-tailed phospholipid that helps support inner mitochondrial membrane organization, cristae architecture and respiratory protein interactions.

ATP production depends on more than enzymes. The membrane is part of the machine.

Next: what happens when cardiolipin starts to oxidize?

From Chapter 18 of The Carbonated Body
Learn more: https://co2body.com/stevenscott

#Cardiolipin #Mitochondria #CellBiology #Carbogenetics by @carbogenetics

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12 days ago

Just had a great time in Sacramento, CA, joining Mark Bell and his cohost Nsima Inyang on the podcast!

@marksmellybell /
@nsimainyang /

Super nice guys, and we went really in depth about my book, The Carbonated Body, CO₂ therapy, and the role carbon dioxide plays in our bodies. I really appreciated their curiosity and the opportunity to dig into the science beyond the usual quick talking points.

Thanks, Mark and Nsima, for having me and for such a great conversation! Looking forward to sharing the episode with everyone when it’s out. by @carbogenetics

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13 days ago

Why Polyunsaturated Fats Are So Dangerous

Part 2 of the lipid-peroxidation series: why multiple double bonds create vulnerable sites for radical-driven oxidation.

Follow the chemistry from stearic and oleic acid through linoleic acid, arachidonic acid, EPA and DHA. The key comparison is the number of bis-allylic sites, not simply omega-3 versus omega-6.

Chemical susceptibility is not a ranking of dietary health effects. Membrane composition, antioxidant defenses and lipid repair also matter.

Next in Part 3: cardiolipin, the four-tailed fat in your mitochondria.

From Chapter 18 of The Carbonated Body
Learn more: https://co2body.com/stevenscott

#LipidPeroxidation #CellBiology #Biochemistry #Carbogenetics by @carbogenetics

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13 days ago

One radical can start a chain reaction through a cell membrane.

Lipid peroxidation transfers radical damage from one lipid to the next. As oxidized lipids accumulate, membrane organization can change, and secondary products such as 4-HNE and MDA can carry the damage beyond the membrane.

From Chapter 18 of The Carbonated Body
https://co2body.com/stevenscott

#LipidPeroxidation #CellBiology #OxidativeStress #Carbogenetics by @carbogenetics

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17 days ago

Atherosclerosis Has an Oxygen Problem?

Macrophages inside arterial plaque can run short of oxygen, even near oxygenated blood. A mouse study asked what happens when that environment changes.

Carbogen (95% oxygen, 5% carbon dioxide) reduced plaque hypoxia. With daily exposure for four weeks, efferocytosis increased 36%, apoptotic-cell content fell 50%, and necrotic-core expansion was 37% lower than in air-treated mice.

Separate short-exposure blood measurements also showed a marked drop in lactate. The study does not establish that this lactate change caused the improvement in cell clearance.

Study: Marsch et al. (2014), Arteriosclerosis, Thrombosis, and Vascular Biology.
https://doi.org/10.1161/ATVBAHA.114.304023
https://pubmed.ncbi.nlm.nih.gov/25256233/

#Carbogenetics #Atherosclerosis #Hypoxia #Macrophages #Efferocytosis #CellBiology by @carbogenetics

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21 days ago

CO2, Hypoxia & Cancer: The HIF Connection

What connects oxygen, carbon dioxide, intracellular pH and the hypoxia response? This animation follows HIF-alpha turnover, tumor adaptation, human oxygenation studies and the experimental pH/lysosome connection reported by Selfridge and colleagues.

Studies featured:
Selfridge et al. (2016): https://doi.org/10.1074/jbc.M116.713941
Human tissue oxygenation: https://doi.org/10.1046/j.1365-2044.2003.03193.x
Carbogen and tumor oxygenation: https://doi.org/10.1016/S0167-8140(98)00123-6

#Carbogenetics #HIF #Hypoxia #CancerMetabolism #CellBiology #CarbonDioxide by @carbogenetics

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21 days ago

Cancer: Genetic Mutations or Environment?

Mutations can be powerful drivers of cancer. But could changes in and around the cell sometimes begin earlier?

Cellular stress can contribute to DNA damage and genomic instability. In a specific 3D breast-cell model, altering cell-matrix signaling restored more organized, growth-suppressed behavior without genetic correction. That does not prove the environment always comes first.

This episode explores a hypothesis: in some cancers, cellular and environmental disruption may precede genetic changes, with both becoming part of a feedback process.

Part 4 of our cancer metabolism series.

What changed in and around the cell before those mutations appeared?

AI-assisted scientific animation; molecular structures are illustrative.

#CancerMetabolism #CellBiology #TumorMicroenvironment #Carbogenetics by @carbogenetics

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a month ago