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Where scholarship and innovation meet.
Official account for the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences. #HarvardGriffinGSAS
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Arya Rao’s commitment to medicine began in the small farming community of Big Rapids, Michigan, where she watched her parents, both physicians and immigrants from India, dedicate their lives to caring for their neighbors. Now an MD-PhD student at Harvard Medical School, Harvard Griffin GSAS, and MIT, Rao is combining that same commitment to patient care with cutting-edge research that could make medicine more precise and personalized.

At the Broad Institute of Harvard and MIT, Rao uses artificial intelligence (AI) and evolutionary genetics to identify potential therapeutic targets and engineer synthetic DNA sequences that control where and how strongly genes are expressed. Her research could help advance gene therapies for diseases such as malaria and Duchenne muscular dystrophy, addressing challenges that have limited the effectiveness and safety of existing treatments. By learning from the genetic adaptations shaped by natural selection, Rao hopes to uncover new possibilities for treating disease.

For Rao, the ultimate goal is to bring scientific discovery back to the patient. She hopes to become a reconstructive surgeon specializing in pediatric care, bridging molecular research and clinical practice to improve outcomes for children. “Patient care is what drives me,” she says. “I love the science, and I’m interested in how we can make interventions more precise at every scale. But at the end of the day, I want to be a physician who can bring that work back to the person in front of me.”

#HarvardMed #HarvardGSAS #PhysicianScientist A person in a lab coat with "Broad Institute" written on it stands confidently with arms crossed in a laboratory setting. Shelves and scientific equipment are visible in the background.
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More than a billion people worldwide live with migraine, a debilitating neurological disorder associated with intense head pain, sensory sensitivity, and other complex symptoms that can last hours, days, or even weeks.

AJ Schick, a sixth-year Harvard Griffin GSAS PhD student in the chemical biology program at Harvard Medical School, who is working with HMS Professor Stephen Haggarty at Massachusetts General Hospital, aims to better understand the molecular mechanisms behind the condition and improve treatment options for patients.

By testing existing medications and other compounds in cell models, he hopes to identify the proteins and biological pathways that regulate the secretion of calcitonin gene-related peptide (CGRP), a molecule that causes many migraine symptoms. These discoveries could help move migraine treatment beyond trial and error toward therapies that more precisely target the disease’s underlying biology, offering relief to hundreds of millions of sufferers, including Schick’s own mother.

#HarvardGSAS #HarvardMed #migraine
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Fitness landscape design (FLD) is a reality!
Thank you to the National Academy of Sciences, the American Physical Society, and the Harvard University Faculty of Arts and Sciences! Read more at link in bio!
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