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Mass General Brigham Research

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Medicine changes lives, research changes the world. @massgeneralbrigham

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A Medicare policy change you’ve probably never heard about lowered some prescription drug prices by more than 20%! 💊💰 #medicare #drugpricing #jamanetworkopen #healthpolicy #pharmacy

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Overdoses & poisonings are now the **3rd leading cause of death** for US children aged 1-19. Yet in our new study of nearly 230,000 Medicaid-enrolled young people diagnosed with opioid addiction, only about 1 in 6 received medication to treat it.

Counseling has value. But the lifesaving medications recommended for all ages, including teens, are so often left out of the plan.

Families: it’s okay to ask a treatment program, “Do you offer medications?”

Out today in JAMA Network Open:
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2854760

#childhealth #addictionawareness #recoveryispossible #pediatrics #parentingteens

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More than a billion people worldwide live with migraine, a debilitating neurological disorder associated with intense head pain, sensory sensitivity, and other complex symptoms that can last hours, days, or even weeks.

AJ Schick, a sixth-year Harvard Griffin GSAS PhD student in the chemical biology program at Harvard Medical School, who is working with HMS Professor Stephen Haggarty at Massachusetts General Hospital, aims to better understand the molecular mechanisms behind the condition and improve treatment options for patients.

By testing existing medications and other compounds in cell models, he hopes to identify the proteins and biological pathways that regulate the secretion of calcitonin gene-related peptide (CGRP), a molecule that causes many migraine symptoms. These discoveries could help move migraine treatment beyond trial and error toward therapies that more precisely target the disease’s underlying biology, offering relief to hundreds of millions of sufferers, including Schick’s own mother.

#HarvardGSAS #HarvardMed #migraine

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AOFAS 2026 Recap!

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Congratulations to Drs. Mark Clapp, Taylor Freret, and colleagues on their recent publication in JAMA!
Building on the 2016 C/SOAP trial, the study found that increased adoption of azithromycin for unscheduled cesarean deliveries was accompanied by a reduction in postpartum infections across the U.S. since the trial’s publication. Read more using the link in our bio! #mgbobgyn #research #csection #womenshealth

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Tim Andrews, who received a genetically edited pig kidney in January 2025, became the recipient of a donated human kidney in January 2026. His case represents the longest dialysis-free survival following porcine (pig) kidney xenotransplantation in a living human and the first transition to human kidney transplantation.

In a new paper, Harvard Medical School physician-scientists at Massachusetts General Hospital and colleagues detail Andrews’ experience and how xenotransplantation is moving closer to achieving its promise of bridging the gap between end-stage kidney failure and human kidney transplantation, allowing a patient to forgo dialysis in the meantime.

The authors report that Andrews, who was 66 at the time of xenotransplantation, successfully lived with the genetically edited kidney for 271 days — during which he did not need dialysis — before receiving the human kidney.

“The organ shortage is the greatest crisis we have right now in transplantation,” said lead author Leonardo Riella, the HMS Harold and Ellen Danser Associate Professor of Surgery at Mass General and medical director for kidney transplantation at Mass General Brigham.

“Our vision is that xenotransplantation could help address this gap — initially as a bridge to get patients off dialysis while they wait for a human donor kidney, and potentially, as we establish long-term safety and durability, as a destination therapy in its own right,” he said.

#HarvardMed #ClinicalResearch #KidneyTransplant Two medical professionals in white coats and face masks are attending to a patient in a hospital room. The patient is sitting upright in a hospital bed. One professional is holding a stethoscope to the patient's chest. Medical equipment is visible in the background.

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Where you live, and what your community earns, may shape your access to specialized foot and ankle care.
Our latest FARIL study mapped 950 orthopaedic foot and ankle surgeons across the U.S. and identified substantial geographic and socioeconomic disparities. Counties with a specialist had significantly higher household incomes and lower poverty rates, while surgeon availability varied markedly across regions and rural communities.
Improving access will require more than increasing numbers, it requires building the workforce where it is needed most.
#HealthcareDisparities #HealthEquity #FootAndAnkleSurgery #HealthcareAccess #OrthopaedicSurgery

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BOSTON, Massachusetts

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Join us on September 12, 2026! With your help, we can continue to fight Cancer, help researchers, develop protocols, partner with families (so they don’t have to navigate the disease alone. Ask us about our Ambassador Program!) — We officially became a 501C3 this summer! Partnering with Mass General Brigham, we have the best conditions for helping to save lives! Early detection, new therapies, better protocols. Cancer diagnosis’ and treatments have come so far - every year there are better options.
Early Detection. Family Support. Trials. Better Protocols. We hope as we grow our Foundation, that we will be able to make life better — and healthier, for many. Please join us on September 12, in our backyard, to DOmor for Cancer Care and Research. You can donate, buy tickets and become a sponsor at www.domor.org

Chef Abby Gray is providing the food!
#domor #domorforcancerresearch #domorforcancercaregala #501c3 #buytickets

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How much side-to-side difference is “normal” in the Lisfranc joint? 🦶

Our latest FARIL-MGB study used bilateral 3D weightbearing CT to establish normal contralateral variation and objective thresholds for subtle Lisfranc instability.

In healthy feet, median side-to-side variation was ≤12%, while Lisfranc instability showed substantially greater differences. Diagnostic cutoffs were 20% for volume, 26% for area, and 34% for diastasis.

These findings reinforce the value of using the patient’s own contralateral foot as an internal control, especially when subtle instability is difficult to detect on conventional imaging.

#LisfrancInjury #WeightbearingCT #FootAndAnkleSurgery #OrthopaedicImaging #SportsMedicine

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Lab Days
Brigham and Women’s Hospital
Harvard Medical School

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👁️🔬 Congratulations to the 2026 Harvard Ophthalmology Research Scholars Program class!

Led by Ophthalmologist Silas Wang, MD, and Associate Scientist Alex Bowers, PhD, the Harvard Ophthalmology Research Scholars Program at Mass Eye and Ear helps medical students with limited access to the field build a strong foundation for careers in ophthalmology through research, clinical exposure, mentorship and career development.

This summer, the scholars spent eight weeks conducting vision research, shadowing in ophthalmology clinics and the OR, participating in a surgical skills wet lab with Harvard Ophthalmology residents and connecting with mentors throughout the program.

We are proud to support these talented medical students and are excited to follow their journeys in vision research and patient care. A scholar conducting laboratory research using a pipette at a lab bench.

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