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@researchsleep

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Advancing sleep and circadian science.
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For World Mental Health Day, I wanted to share something a little more personal.

I’ve written a special edition in my newsletter about my own lived experience of grief, anxiety and insomnia, following the sudden loss of my sister in 2020.

It’s a story I’ve shared parts of before, but this time I’ve written more openly about what happened behind closed doors, how grief changed my relationship with sleep, and the journey that eventually led me to create The Cognitive Edit.

If you’ve ever struggled with sleep, experienced anxiety or found yourself trying to navigate life after loss, I hope something in my story resonates with you.

You can read the full letter by subscribing to my free Sleep & Wellness newsletter via the link in my bio. 💚

And if there’s one thing I’ve learnt, it’s that you never really know what somebody else is going through.

Be kind.

Michelle x

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Most CPAP intolerance isn’t a willpower problem, it’s a fit problem. Wrong mask, wrong pressure setting, untreated nasal congestion, claustrophobia nobody addressed, aerophagia nobody explained or that dreadful feeling like your CPAP is smothering you at night time. Any one of those will make a person quit in week two and walk away thinking “I just can’t do CPAP.”

The real question isn’t “did CPAP fail.” It’s “what specifically isn’t working, and what’s the next thing to try.” Sometimes that’s a mask swap. Sometimes it’s a pressure adjustment. Sometimes it’s a completely different therapy path. But almost nobody should stop at “I tried it once and it didn’t work.”

If you’ve been told CPAP just isn’t for you, or you told yourself that, I’d push back on that a little.

Rav Sleep MD
@sauravluthra

#SleepApnea #CPAP #SleepMedicine #SleepDoctor #sleep

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September is a great time for a reset.

Just a few simple habits that can support a healthier mind and better sleep.

This month, focus on:

- A consistent wake-up time
- Morning daylight
- Daily movement
- Mental downtime
- A calmer evening routine

Consistency over motivation.

Which one do you need to work on this September?

Rav Sleep MD
@sauravluthra

#sleep #september #healthylifestyle #doctor #outdoors

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Narcolepsy type 1 is fundamentally an orexin deficiency disorder.

The neurons that produce orexin are lost, disrupting the brain’s ability to maintain wakefulness and stabilize sleep/wake transitions.

Until now, our medications have largely treated the consequences: excessive daytime sleepiness, cataplexy, and other symptoms.

Oveporexton (Orzeyful) changes the conversation.

It is a selective orexin receptor 2 (OX2R) agonist designed to restore the missing orexin signaling — without replacing the lost neurons themselves.

The FDA approved it in August 2026 for adults with narcolepsy type 1.

Why is this such a big deal?

Because for the first time, we’re pharmacologically targeting the underlying biology of NT1 rather than treating individual symptoms alone.

I put together a quick breakdown of:
• How it works
• What the Phase 3 trials showed
• Dosing and safety
• What this could mean for the future of narcolepsy treatment

Swipe through.

And if you have narcolepsy or care for patients with NT1: what questions do you have?

Rav Sleep MD
@sauravluthra

#Narcolepsy #sleep #Orexin #SleepDoctor #health

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🎙️ SACH Research Lab on the Sleep Research Society Podcast🎙️

SACH Research founder, Jasmine Niazi, was featured on the latest episode of the SRS Podcast, highlighting the lab's research presented at SLEEP 2026 in Baltimore and the journey behind it.

The episode featured this year’s Trainee Merit Award winners, highlighting their journeys into sleep research, their research presented at SLEEP, and their future aspirations for advancing culturally responsive and community-centered sleep science.

Thank you again to the Sleep Research Society for the platform to share this work and amplify research that seeks to advance sleep health equity in our communities!

🎧 Listen to the SRS Podcast feature and learn more about the research presented at SLEEP 2026: https://sleepresearchsociety.org/career-advancement/srs-podcasts/

#SACHResearch #sleepresearch #Sleep2026 #SleepResearchSociety #sleephealth #Ramadan #muslimhealth #CommunityEngagedResearch

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🚨 FDA APPROVES ORZEYFUL — 1st drug for Narcolepsy Type 1

🧠 Fixes the root cause — restores lost orexin signaling
💊 Oral OX2R agonist — oveporexton (Takeda)
☀️ 2 doses every morning, 3–5 hrs apart
📈 +12–19 min more wakefulness vs. placebo
⬇️ 60–75% fewer cataplexy episodes
😴 Also improves nighttime sleep + cognition
⚠️ Watch for: insomnia, urgent urination, muscle enzyme (CPK) rise
🚫 Don’t mix with strong CYP3A inhibitors
🏛️ DEA scheduling still pending — not available yet
📅 Approved Aug 5, 2026

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I might be dancing, but I'm dead serious about this one.

Quick catch up if you're new here: Congress just voted to lock the whole country into permanent daylight saving time. Sounds like a win, since nobody loves changing clocks. But as a sleep doctor, I promise they picked the wrong one. Permanent DST means dark winter mornings for months, and morning light is exactly what your body clock needs to run right. The science backs permanent STANDARD time instead, and so does basically everyone in my field.

So I asked hundreds of thousands of you which team you're on. The results are not close, and honestly they made me want to dance.

The Senate votes next, and I'll be right here breaking down every twist as it moves, plus what it actually means for your sleep.

Cast your vote in the comments: team standard or team daylight? And check my recent post for the full breakdown if you missed it.

#sleephealth #sleepdoctor #circadianrhythm #sleepscience #daylightsavingtime

Which team are you?

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Hard truths for Congress, from a sleep doctor who's not afraid to hurt their feelings.

The House just voted 308 to 117 to put America on permanent daylight saving time. I know it sounds like a win. Nobody wants to change clocks anymore, including me.

But this is not a gift of more daylight. It is the same daylight with the dark moved to your morning.

Under permanent DST: winter sunrises after 8 or 9 AM. Kids at bus stops in the dark. Body clocks misaligned for months at a time. Worse sleep, lower mood, more crashes. We even tested it in 1974, and it was repealed in under a year.

The American Academy of Sleep Medicine, the AMA, and the Sleep Research Society all back the fix: end the switch, keep permanent standard time.

The Senate votes next, and their offices count calls, not vibes. Comment NEWSLETTER and I'll send you my full breakdown plus the exact script to use when you call your senators.

#sleephealth #sleepdoctor #sleeptips #circadianrhythm #sleepscience

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06/14-17 SLEEP2026 (Baltimore 🇺🇸)
@aasmorg @researchsleep

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Circadian Sleep Disorders Network exhibited at #SLEEP2026, hosted by @aasmorg and @researchsleep. The annual international sleep conference - held this year in Baltimore, MD - had more than 5,000 attendees.

Peter Mansbach and Alex Wharton staffed the booth in the Advocacy Pavilion. Thanks to the many conference attendees who stopped by with their questions about Delayed Sleep Phase Disorder (#DSPD) and Non-24 Hour Disorder (#non24).

We attended the @aasmorg Foundation Impact Mixer and a book launch among other events. It was wonderful to reconnect with colleagues from several advocacy organizations including @project_sleep, @apneapartners @wakeupnarcolepsy and @startschooll8r

#circadian #sleepadvocacy

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Sleep Research Society (SRS) in Mount Prospect, Illinois, United States (US), advances sleep and circadian science, exploring how lifestyle and screen use affect sleep quality. Its research informs interventions, helping #shape evidence-based strategies for healthier sleep habits worldwide.

#SleepResearchSociety #CircadianScience #SleepQuality #HealthySleepHabits #LifestyleImpact #ScreenTimeEffects #EvidenceBasedSleep #SleepAwareness #MountProspectResearch #SleepInterventions

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Parasomnia: nightmares and RBD , AASM guidelines

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